The Kopito laboratory seeks a molecular understanding of how cells maintain the integrity of their proteomes and ribosomes. Our laboratory uses state-of-the-art cell biological, genetic, structural, and functional genomic approaches to understand how proteins are correctly synthesized, folded and assembled in the mammalian secretory pathway, how errors in this process are detected and how abnormal proteins are destroyed by the ubiquitin-proteasome system and how damaged ribosomes are detected and repaired.